: Could microbes develop resistance against Povidone Iodine solution? why or why not?
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In theory, it is possible for microbes to develop resistance to PVP-I or any other antiseptic solution. This could happen through a process called genetic mutation, where a small change in the microbe’s DNA leads to a change in its physiology making it resistant to the antiseptic solution . However, it is important to note that the development of resistance to PVP-I is considered to be relatively low. This is because the mechanism of action of PVP-I is not specific to any one type of microbe, but rather it works by destroying the outer membrane and cells structure of a wide range of organisms, this broad mechanism of action makes it difficult for any microbe to develop a resistance to it.
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