I read an interesting article a few years ago that theorized DOMS were caused by nerve growth. Whenever you engaged in activities that required new muscle groups your body would increase nerve growth to increase muscle recruitment. I’ve never heard it talked about it since but it made sense to me. I think this is the paper that the article was referencing, but definitely not eli5.
https://jps.biomedcentral.com/articles/10.1007/s12576-015-0397-0
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