: Do GABA receptors got anything to do with memory?

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And if they are damaged, can they get restored?

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GABA is one of the main inhibitory neurotransmitters in the brain. This means that it’s a chemical messenger which prevents signals being sent from other neurons, or brain cells.

The receptors are what GABA attaches to, to cause this effect and there are a number of different types. We do have reason to believe it’s involved in memory, both from the fact it’s very commonly used in a lot of pathways (networks of brain cells that talk together to achieve things) and some direct evidence. For example, animal studies have shown that if you release GABA antagonists (which stop GABA from binding to those receptors) into certain parts of an animals brain, it impairs memory function.

As for their restoration, the short answer is yes, up to a point. Receptors themselves can be broken down and rebuilt and this happens regularly for lots of receptors. If you took a huge amount of a drug that knocked out your GABA system entirely, you’d probably be dead or at least suffer a seizure, but in terms of minor damage to individual receptors, sure.