Do prime numbers still work in base that’s isn’t 10?

Question

I’ve started reading a lot of sci-fi and the humans always attempt to communicate with aliens using prime numbers, but if they use a counting system that _isn’t_ base10, would the prime numbers still make sense?

In: 2249

Answer 1

Bases are pretty much just different notation to write the same numbers. The number ten is equal to ten whatever base you write it in.

So long as you can communicate [a quantity of (number)] with them you can get the meaning across. 2 blobs, 3 blobs, 5 blobs, etc.