Do prime numbers still work in base that’s isn’t 10?

Question

I’ve started reading a lot of sci-fi and the humans always attempt to communicate with aliens using prime numbers, but if they use a counting system that _isn’t_ base10, would the prime numbers still make sense?

In: 2249

Answer 1

The base used to write numbers makes no difference to whether they are prime or not. That’s part of the advantage of using primes; they are universal.