I would say in practice, no. But in theory, yes.
As I see it, the key factors are simultaneity of detonation and the velocity of detonation.
If the two smaller bombs were detonated precisely simultaneously, and if the velocity of detonation of each of the smaller bombs was equal to that of the single larger bomb, then the resulting explosions should be more or less identical in terms of force. But for these same reasons it would be difficult to achieve in practice.
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