I work in downstream clinical manufacturing and I’ve always been curious to understand why process fluid will not move through tubing if the pump is post-filter? There was a time where I accidentally placed the pump on the outlet side and the pump started making noises as if it was drawing up air despite the inlet tubing being fully submerged in liquid.
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you cannot pull a liquid, so on when the the pump is on the output all it can do is lower the pressure and let the (low) pressure before the filter push the liquid through, if that is not enough the pump will just be spinning making bubbles because the pressure gets so low the liquid boils. It is like pushing a rope
if the pump is on the input of the filter there is no restriction input of the pump and the only limit on pressure on the filter is how much pressure the pump can make. Like pulling a rope
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