I work in downstream clinical manufacturing and I’ve always been curious to understand why process fluid will not move through tubing if the pump is post-filter? There was a time where I accidentally placed the pump on the outlet side and the pump started making noises as if it was drawing up air despite the inlet tubing being fully submerged in liquid.
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Post filter the resistance pulling fluid through the filter causes fluid pressure to drop between the filter and pump. That leads to increased cavitation (bubbles forming from water vapor on the pump blades) It’s super unhealthy for most pumps because the bubbles collapsing is like a ton of tiny hammers, in addition to it just not pumping as well. Similar happens if you run a pump too fast, or with other things that drop pressure pre-pump like pulling fluid upwards.
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