Yes, Aluminium etch primers chemically react and bond to the substrate. Copper Boat Primer bonds to the wood, and stops mould. Internal paints are not so fussy, I often use White Emullsion as a wood primer indoors. Steel needs a primer made for steel. Aeroplanes need special primers. I have literally seen four coats of paint slowly roll off a wing as the surface was not degreased and etch primed first. It nearly cost the company a few million pounds in lost contracts.
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