ELI5- chemically speaking, why is it so difficult to recreate life in a lab?

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Basically the title

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1. We don’t know if we can to begin with.
2. We don’t know where the line between a inorganic and organic is.
3. We don’t know the origin of life.
4. Any life made artificially would start off tiny, smaller than bacteria, and it would barely meet the definition of a living thing.

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