eli5: Do extreme differences in the frequency of eating affect nutritional absorbtion if the total quantity of food is the same?

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For example, let’s say that I typically consume 21,000 calories in a week. If I space that out as evenly as possible, that would be 1,000 calories every 8 hours. If I were to eat 10,500 calories in a single sitting twice during that week, would my body be able to absorb the same number of calories?

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