Many answers have mentioned time zone change, but another factor to consider is the pressure and humidity during the prolonged period an airplane.
In a typical passenger aircraft, the air is very dry and the air pressure makes it feel like you’re sitting at around 8000 feet elevation for most of the trip. (Newer aircraft like the Boeing 787 and Airbus A350 do a bit better on both of these.)
That will have an effect on how you feel, especially after several hours.
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