Jet lag is part. Being confined to a very small seat for a very long time is part. Dehydration is also part.
Air in an aircraft is pressurized from the compressor section of the jet turbine. It starts out at -40F/C, then gets heated to a few hundred degrees. Any moisture in it is absolutely destroyed.
Then it gets cooled off, and pumped into the cabin.
The relative humidity in an aircraft at altitude is 10% or less, and all that comes from OTHER people’s breath.
If you seriously want to feel better after a long flight, wear a mask and drink at least 1-2 liters of water. It’ll keep you hydrated better.
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