In addition to the other answers, there can also be issues of similar chemicals reacting. If you’re doing a urine test on an athlete for a performance in hanging drug, and you’re using a test that will turn red if the drug is present, it’s possible the athlete is on a rare medication that just so happens to react with the test in the same way. (I don’t know if that situation specifically has ever happened, but that’s the sort of thing that I’m talking about)
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