Brain cells have many different chemical receptors. Your brain cells communicate with each other and send information by releasing chemicals to other brain cells. When you take a substance, the chemicals from whatever you took can either fit closely enough into these cell receptors to simulate the sending of information, or they can block the cell receptors from receiving any information your other brain cells are sending. Most substances are the first option, meaning they overactivate certain parts of the brain (or make signals in those parts easier to fire).
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