With the sweet spot between trial and error, past experience, educated guesses, market research and a pinch of sheer luck.
Also, since nothing comes for free, every seller has their own *minimum acceptable margin* (might be negative in some cases, but still it has a value).
So you know what is the minimum sell price you are willing to accept, now you just have to guess-stimate the maximum purchase price your customers are willing to pay (and hope it is higher than your value)
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