Your immune cells have antibodies that attach to foreign invaders. A Rh-negative person has antibodies against Rh-positive blood cells. When an immune cell detects that its antibodies have been activated, it’ll multiply a bunch. Some of the resulting cells will fight the invader, others will hang around in case it returns years later.
RhoGAM floods your blood with antibodies against the same foreign blood cells, and those antibodies attach to them before your immune cells get a chance to do so. This means your immune system can’t “see” them, and doesn’t create an army in order to fight them.
It’s quite a bit more complicated, but this is the gist of it.
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