eli5: how does domperidone work?

104 viewsChemistryOther

this was prescribed to me for bloating, and not sure how it really works, or how i can make it work better

In: Chemistry

Anonymous 0 Comments

In pharmacology, domperidone is an antagonist of dopamine receptors type 2 and 3. This means that it stops dopamine from binding to these receptors.

In your gut, dopamine binds to dopamine 2 receptors (D2) inhibiting your intestinal motility. This causes food to spend more time in your gut, making you bloated. By blocking those D2 receptors, domperidone stops dopamine from binding to them and slowing your intestines. By stopping the inhibitory effect of dopamine, we actually speed up intestinal motility, making you feel the need to poo quicker. This also solves your bloating problem.

Take it as prescribed and you’ll have the optimal result.

I hope i’ve cleared this up, but if you have further questions, feel free to ask.