Eli5: How does Saline Solution work within the blood stream?

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Fellows,

I’m reading about donating blood, and they said that in large volume plasma donation, a replacement of saline is added to your blood stream to account for the large volume taken. I’m just wondering how it’s okay to just replace blood with Saline

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Did you donate blood or did you donate plasma? If you donated blood, the saline is more or less to keep you at the right fluid level in your body (the saline solution matches the salinity of blood). It does not replace the loss of blood cells, so you will feel anemic and it will take your body several weeks to replace the lost blood cells.

If you donated just plasma, the blood cells are given back to you. Again the saline replaces the lost fluid, but since you did not lose blood cells you won’t be anemic. With such an exchange in plasma donation, you are losing antibodies and hemoglobin for the most part, so you have lost protein that you need to replace. This is done much more quickly than regenerating blood cells

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