Depends on the level of particles. If you’re talking atoms, yes, they break/”are destroyed” into their subcomponents, mainly protons/neutrons, and recombine.
If you’re talking protons and neutrons, they can also break down themselves in neutron stars, or when neutron stars collide in a kilonova (quarks soup), that’s when they recombine to form heavier atoms. Also happens in particles accelerators.
Breaking quarks though, I’m not sure.
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