Eli5: If caffeine connects to the same receptors as adenosine, why does it have the opposite effect?

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I understand that it doesn’t allow adenosine to connect to the receptors, but if the receptor doesn’t know which molecule connected, it should unleash the same reaction, right?

In: Chemistry

2 Answers

Anonymous 0 Comments

Thats because your idea is wrong, not every molecule causes a reaction when connected its only agonists that cause the receptor to change what its doing. Caffeine probably is an antagonist which stops the action of that receptor but I didnt look into what adenosine or caffeine does exactly.

Anonymous 0 Comments

In the simplest terms, Adenosine has a reaction with the receptor, caffeine does not have a reaction. Thus, it blocks adenosine from being effective.

It’s not that caffeine does the opposite, it just ‘plugs’ the hole and keeps adenosine from doing its job.