eli5 – If our cells only turn a certain amount of times before we die. Does causing micro damage from resistance training shorten our lifespan?

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I’m not even sure how to put into words my question but I’ll try.

From what I understand telomeres shorten during cell turnover which causes ageing. Therefore do activities that cause cellular damage like resistance training, tattoo or laser resurfacing etc shorten your lifespan or cause you to age?

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5 Answers

Anonymous 0 Comments

The way DNA replicates to termination is a little different than just apoptosis. Let’s see if I can explain.

Cells have a natural life cycle, and when they age out, they have a natural self-termination called apoptosis. This is built into the structures and has a set timeline. If you’re talking about cells that aren’t manufactured somewhere like blood cells in marrow, they replicate via mitosis and just keep going.

However! Oxidative damage to the telomares shortens the terminus of the DNA. This is directly related to the effects of aging and age-related changes. This happens on a molecular level.

What you’re describing happens at a *cellular* level, and the body has systems in place to account for that (for the most part). You’re not prematurely aging yourself by working out. If anything, you’re keeping your systems stimulated to keep up on cellular “housekeeping,” to include removal of dead or dying cells more appropriately.

… in short, you’re fine!

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