eli5: If your leg gets amputated, how does your body know to not produce enough blood to replace what was lost?
In: 2195
The kidney is your oxygen sensor. If the tissue inside the kidney has low oxygen the kidney produces erythropoietin. Erythropoietin makes the bone marrow produce more red blood cells. The control of blood volume is a separate process, based on brain and kidney released hormones (anti diuretic hormone, renin, angiotensin and aldosterone).
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