Sure.
Perhaps the first and most flameouts is Koch’s Postulates, which were proposed to determine if a bacteria caused a disease. Nothing about causal mechanism. See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775492/#:~:text=As%20originally%20stated%2C%20the%20four,%3B%20and%20finally%20(4)%20The
Even today, if Koch’s postulates are met, causation would be widely accepted as shown.
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