Eli5: researching amphetamines and methylphenidates mentions isomers frequently, I don’t get the biochemistry of it

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Don’t even know what isomers do in the body. I’m trying to find a stimulant that will work well with my brain, it tells me a lot about how my brain works when I can tolerate vyvanse over adderall. I’ve researched on every single stimulant available & they essentially all work on dopamine, seratonin & the other one lmao. I know some have just dextro & then dextro and levo, I get the chemistry of it but how the chemistry works in the brain is confusing me, I get that some tell dopamine to keep producing & some overflow dopamine, I just don’t get what isomers & the many other things it’s doing. I want to know every single detail of what they’re doing to my body and why. I want to find the most effective one for me & know how to keep myself healthy based on what it effects.

Note: I see a psychiatrist but she is not going to teach me chemistry so this is for my own awareness. It is also fascinating. Even if I were to take medical advice, a medical professional would have to approve it so I don’t get those comments.

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Anonymous 0 Comments

This is skirting really close to medical advice. You should talk to said psychiatrist about what to study. Khan Academy’s organic chemistry course would be a good primer. https://www.khanacademy.org/science/organic-chemistry

The short version is that isomers are different compounds that have the same formula but the atoms are connected in different ways. Biological molecules often have a lock and key kind of fit (it’s of course more nuanced than that.

Because carbon can make 4 bonds, if all 4 have different things attached to it then they can make two mirror images that can’t be superimposed. That is like your left hand and right hand. Even people studying organic get tripped up on that. YouTube search for stereochemistry so you can have it shown visually. I searched and two from this channel came up: https://www.youtube.com/@TheOrganicChemistryTutor

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