Chemical burns are real, but the chemical in fight club; lye, is not nearly so nasty as depicted in the movie. Working with lye with bare hands can result in raw tender skin, so it is recommended to use gloves, but it won’t instantly leave a deep chemical burn.
There are other chemicals that can burn your skin as badly as depicted in the movie, or even worse. These chemicals aren’t used in soap making, while lye is, so in the plot of Fight Club it makes sense that Tyler has lye on hand.
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