It is more difficult to measure mass in space for sure! The main thing mass gives you in a weightless environment is inertia. So how much force do you have to apply to something to get it moving.
For example, a paperclip has very little mass, so you could gently push it and send it sailing across the space station. The new toilet, I presume, is pretty massive, so it would take a lot of force to start (or stop!) It moving.
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