It’s well known that drugs such as antidepressants (particularly SSRIs) and benzodiazepines suppress REM sleep,it’s also well known that REM sleep is crucial for memory,cognition,consolidation of memory and many other important functions,my question is what are the long term outcomes of drugs that suppress REM?
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Michael Jackson was given Propofol to induce sleep. It was administered intravenously by his personal physican. No REM sleep occurs when Propofol is used. He was given this drug every night for several weeks as he was preparing for a world tour that would never happen. Those around him noticed his troubling decline during this time. He wasn’t able to remember song lyrics or dance moves. He exhibited symptoms of dementia. For Michael Jackson the consequence of a drug that suppressed REM sleep was death.
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