Eli5: What is the bodies process of breaking out in hives?

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Is it something in yo ur bloodstream that presents on the skin? What exactly are they?

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Hives, or Urticaria, are caused by your body’s immune system when it doesn’t like something. So like once in a while your body is super dumb and it decided to over react to something that normally is just fine, these reactions are called hypersensitivity reactions or more commonly allergic or anaphylactic reactions. Hives are part of this. Along with the T-Cells and B-Cells your body uses Histamine to help combat intruders. Histamines are one of the chemicals that causes swelling in your body aka the bodies inflammation response. When you have one of these over-reactions, your body starts pumping these out like crazy cause again your body is dumb. When histamines hit their receptors it triggers that swelling response. This can be really bad like when it affects the airways but when they trigger in the capillary beds, it causes them to dilate and allow fluids to seep into the surround tissue giving you those welts. That’s the main player but there is a lot of other stuff that helps by changing the permeability of cell walls etc but Histamines are your main culprit.