Why did the human body develop the ability to engage with cannabinoids? I’ve heard people postulating that we’re practically build to get high, as a justification for cannabis usage, but I can’t really believe it would be the main cause for this specific natural selection. I mean; from a darwinian perspective it doesn’t really make sense – how would getting high be survival of the fittest? Also, there exist other cannabinoids than THC, so what is the effect of these, and how present are they in our daily lives and what are the effect of these?
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A common practice in pharmacology is to name receptors after a chemical that can bind to them in an experimental setting. Muscarinic receptors bind to muscarine, nicotonic receptors bind to nictotine etc. Accordingly, the so called cannabinoid receptors are so named for what they were found to bind to experimentally.
Like all other receptors, they are acted upon by endogenous chemicals or neurotransmitters, (the main one is called anandamide off the top my head, will need to refresh my memory) to bring about a huge variety of effects throughout the body..
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