The specific chemistry and physical arrangement of the building blocks of spider silk is *extremely* difficult to replicate industrially.
In simple terms, spider silk is made up of an arrangement of “bricks” (nano crystals of proteins in an arrangement called “beta sheets”), with elastic stuff between them (amorphous proteins linking the beta sheets). It is critically important that you have these materials in this sequence, otherwise you lose all the useful properties and it’s just a pile of gooey protein.
Spider spinnerets are finely constructed for arranging these proteins in exactly the shape and order they need to be in order to produce this strength. Industrial synthesis can get us the right *compounds,* that part is easy. It’s much, much harder to get the right *structure,* which is the most important part.
If someone can figure out how to easily (=cheaply and quickly) make those strands, structure and all, without needing actual spiders, then they could make spider silk an industrial commodity. No one has quite solved this problem yet.
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