Having gone through rapid decompression from 5,000 to 25,000 feet, I’ll tell you it’s fine. You need extra oxygen if you’re going to stay up at 25k, but you won’t get the bends or other problems. If it happens in real life rather than in a pressure/vacuum tank, the doctors will check you out, but you’ll be fine as long as you’ve got oxygen available.
For most people, going from 500 to 1000 would make your ears pop to equalize the pressure. You wouldn’t even notice a difference otherwise.
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