Eli5: When we sleep, spinal fluid washes waste from our brain. What exactly is “waste” in the brain?
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Major components are adenine nucleotides, secreted glyph and from Astrocytes, lots of the cleaved targets of gamma secretases, which beta amyloid peptides are one of them.
Even after one night of bad sleep, or not enough hours of sleep, researches find increased levels of amyloid on a PET scan. Sort of suggesting that that CSF waves during sleep didn’t wash out the secreted amyloid peptides from the night before.
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