Drugs are typically absorbed very well by mucous membranes, which include your nose lining, mouth and other areas.
They transit directly from there to the bloodstream and thus take effect extremely quickly without losing strength.
Drugs taken orally first have to transit your digestive system, which degrades them, and then has to get through your liver, which is an even more savage environment. Only then do they get out into the wider bloodstream and take effect.
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