[ELI5] Why are medications dispensed at very specific/seemingly almost spontaneous solution/dosage amounts?

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I am sure there is a reason why. But, I have always wondered if a slight variation would change things.

For example. A bag of sodium chloride 0.9% is commonly dispensed at hospitals and clinics. Why is it *specifically* 0.9%? Would there be a completely different effect if it were, say, 0.10%? Or 0.85%? Or did people just realize this amount happened to work and it became default?

I also have seen medications of random components that will be like *insert chemical* 0.15% or a medication like colchicine at 0.6 MG. Why isn’t it 0.5 MG??

Just curious. Hopefully not a stupid question.

In: Chemistry

3 Answers

Anonymous 0 Comments

Simple reason: 0.9% is compatible with our blood plasma (similar osmolarity) – it doesn’t shrink or swell our cells (cell lysis/destruction), maintaining cell wall integrity. It’s an effective fluid replacement to treat dehydration and maintain electrolyte balance. It’s safe to use with IV meds.

As far as drug dosages, those are what have been determined as efficacious (correct treatment amount) and safe. Some drugs have set doses and some are titrated until a positive outcome is achieved.

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