There are 2 additional factors i heard explained to me 20 years ago studying Aeronautical engineering:
Put the engine in the front, because if it crashes, you don’t want the engine to travel through the cabin (and the pilot). Aircraft crash in many orientations, but often nose first.
A propeller is subject to ‘prop wobble’, oscillation in the plane of the propeller. This is passed on to the drive shaft. A long drive shaft flexes / rubs against mounts more, and this leads to greater chance of failure.
Edit: had put vibration instead of oscillation
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