Allergies are your own body’s overreaction, so not quite the same as a substance that directly acts on the humam body in a consistant way. Also, some allergies can be “trained” out, but very carefully and under close medical supervision!
Resistance is something that takes time, both as a species and as an individula.
Pollution is simply too “new” to humans and constantly changing so humanity simply hasn’t had the opportunity to develop consistant defense against it. Of course with the micro plastics found in human blood, maybe we are becoming one with it…
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