[ELI5] Why can we gain resistances to medicine, alcohol, poison, etc. but not so much for allergies or pollutants?

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[ELI5] Why can we gain resistances to medicine, alcohol, poison, etc. but not so much for allergies or pollutants?

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Former football player AJ hawk defeated his shellfish allergy by slowly exposing himself to increasing levels of shellfish over a long period of time

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