In 40 or so chemo infusions I’ve not had any pain, and the anti emetics have gotten me through without vomiting once.
After the first few sessions of frontline I had them change the antihistamines to a non drowsy type so I could drive myself to and from the hospital.
We all cope differently with the drugs, and it would be difficult to know someone was having a bad reaction to a drug if they weren’t awake, you would need an anesthesiologist on hand for every patient, my clinic has 20 chemo chairs to staff
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