Eli5 why can’t we continuously take caffeine and never sleep?

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I work overnight shifts (11pm-7am) and take caffeine pills to stay awake. When I get home, even if I take more caffeine I’m sometimes still too tired and fall asleep. Why does it eventually stop working? Is there some sort of chemical limit? Why can’t caffeine replace sleep for longer periods of time (like days on end)?

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Anonymous 0 Comments

When the fuel light comes on in your car because you’re low on gas, you can make the light turn off temporarily by driving up and down hills and tricking the gauge, but that doesn’t actually put more gas in your car—when it runs out, the car will stop running, even if you somehow tricked the fuel light into turning off (or even broke it). It’s kinda like that. Your body needs sleep to run either way—feeling tired is just the warning light. Caffeine doesn’t replace sleep in the same way that breaking a signal light doesn’t solve the root problem that it turned on to alert you of.

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