Eli5 why can’t we continuously take caffeine and never sleep?

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I work overnight shifts (11pm-7am) and take caffeine pills to stay awake. When I get home, even if I take more caffeine I’m sometimes still too tired and fall asleep. Why does it eventually stop working? Is there some sort of chemical limit? Why can’t caffeine replace sleep for longer periods of time (like days on end)?

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Anonymous 0 Comments

If you’re interested in learning more about what a lack of sleep does, there is a disease called Fatal Familial Insomnia which is a genetic prion disease that stops those afflicted from sleeping. Pretty much 100% fatal. [https://www.bbc.com/future/article/20160118-the-tragic-fate-of-the-people-who-stop-sleeping](https://www.bbc.com/future/article/20160118-the-tragic-fate-of-the-people-who-stop-sleeping)

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