In the 1930s southern Australia was having a terrible time controlling the Grey-back beetle which was destroying sugar cane crops. So they introduced 101 Cane Toads from South America. Cane toads adapted very well to their new environment, and basically killed off not only the beetles but the red-bellied snakes (who ate the toads, but were poisened by them). Without the snakes, the grasshoppers exploded in population, and what do grasshoppers like? Sugar Cane. Australia now has a Cane toad AND a grasshopper problem.
Who knows what would happen if we got rid of fleas?
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