Eli5: why do many medications not work when you have certain stomach problems?

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Why do orally medications not work when you have diarrhea? Aren’t they already resolved in your stomach acid by that point?

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Much of the absorption of food, nutrients and many drugs takes place in the intestines. If you have diarrhea the intake transits through the intestines too quickly and isn’t fully absorbed, hence why diarrhea is often watery

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