eli5: Why do some antibiotics have the potential to make birth control not work?

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They seem to be unrelated at all.

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Anonymous 0 Comments

With the amount of drugs available it’s very common for people to be on two or more drugs at the same time. So, it is important to understand the possible reactions between drugs.

One of the functions of the liver is to metabolize drugs. One of the systems it uses for that is called the CYP450 system. Oral birth control pills are metabolized by the CYP450 system. So if any drugs make that system stronger then more birth control will be metabolized, making it less effective.

Some antibiotics do exactly that. They increase the effect of CYP450, which in turn reduces the effect of birth control pills.

There are many drugs that induce and inhibit that system so the potential drug-drug reactions are very large.

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