Evolution is a constant arms race between predator and prey. As creatures are killed by predators, eventually resistance to the venom develops…so predators have to evolve stronger venom. Go back and forth for a million years, and you have creatures like the mongoose that are nearly immune to most the venom of snakes in their habitat. But the same venom would incapacitate a human in short order.
Something I haven’t seen many people touch on is the *rate* at which the venom kills something, not just the quantity. When a snake or spider bites a prey item, they don’t want to prey item running away and dying far away from them. In addition, prey items struggle, kick, bite, claw, etc. when threatened. Another comment mentioned this in a bit more detail but it’s really bad news if the predator is injured every time it tries to kill prey. By killing something quicker, it reduces this risk.
So the venom isn’t more powerful because it wants to kill bigger things; it’s more powerful because it wants to kill little things faster.
Reason is: that venom isn’t meant for you! The fact that it’s so effective at killing you is more a coincidence than anything.
They evolved with creatures that evolved resistances to their toxins. It was an arm’s race where their prey kept getting better at resisting, so they had to get better at killing.
Then you look at humans, who never had to deal with many venomous things. We were typically above those guys in the food chain, so they never really wanted to use it against us. They only do when a human gets stupid.
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