The fuels are (in most case) quite volatile.
Weight matters. See [Tyranny of the Rocket Equation](https://newspaceeconomy.ca/2023/05/28/the-tyranny-of-the-rocket-equation-an-in-depth-examination/?amp=1) Therefore the structures that contain the fuels and carry the fuels are likely engineered to what humans think the bare minimum to achieve success. Sometimes those calculations are off; Mother Nature can throw some curve balls and it can be challenging to assess some of those conditions to know what to design for.
Sometimes the team changes something, and doesn’t refer back to the requirements nor the dependencies. A change of voltage ultimately caused the “successful failure” of Apollo 13, as the higher voltage wasn’t accounted for in dependent systems.
Latest Answers