eli5 : Why do we gain a tolerance to consuming certain things but not for others?

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Im mainly referring to caffeine like coffee or pre workout. After a while the effects of those will be less than the first time you take it but something like protein powder? How can you not build a tolerance towards it even after, for example, drinking a shake or two a day?

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Anonymous 0 Comments

Caffeine is a drug that directly stimulates receptors. Protein powder is just food. It’s not a drug with an effect.

You can’t have a tolerance to protein powder in the same way you can’t have a tolerance to donuts. I wish! But no, when you eat food, your body digests it. Evolutionarily speaking there’s never been a good reason to not digest and consume fuel that’s been eaten, so there’s no mechanism for that.

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