Caffeine is a drug that directly stimulates receptors. Protein powder is just food. It’s not a drug with an effect.
You can’t have a tolerance to protein powder in the same way you can’t have a tolerance to donuts. I wish! But no, when you eat food, your body digests it. Evolutionarily speaking there’s never been a good reason to not digest and consume fuel that’s been eaten, so there’s no mechanism for that.
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