Testosterone wrecks the human body. When young it promotes growth, but later on in life testosterone acts to interfere with immune responses and causes other problems.
Studies have found that eunuch tend to have less health issues later on in life vs uncastrated men.
https://abcnews.go.com/Health/castration-men-live-longer-eunuchs-studied-korean-records/story?id=17310420
Men are also short one set of chromosome.
The Y chromosome doesn’t encode for outside of determining if you form male sexual organs and features. Where as X chromosome have far more information.
So if you just got one copy of X and your copies is corrupted, you are going to have a bad time
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