It’s a similar reason to why you eat or drink several times a day. Your body is constantly processing and flushing out waste. The purpose of antibiotics is to make your body a hostile environment to an infection. That only works until the infection is completely eliminated, and if the antibiotic is flushed from your system too soon the infection will potentially grow back.
Antibiotics tend to not remain in your system for long, and you wouldn’t want them to linger in your system. Newer ones are probably more targeted, but, in concept, they literally are poison, and can potentially harm beneficial microbes as well, which is why diarrhea and digestive issues are often side-effects of antibiotics. Your digestive system relies on a lot of microbes that technically aren’t part of your body to help break down things you eat. So you don’t want to take a single larger dose, because it would potentially have toxic side effects for your body.
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