eli5 why does caffeine seem completely ineffective at times

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There are days where I can have a cup of tea or a can of redbull or even an espresso and just go to sleep in 15-20 minutes. But there are also days where it actually works. What causes this erratic behaviour of caffeine on the mind?

PS: I don’t intake a large amount of caffeine regularly but it’s behaviour is kinda weird

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Anonymous 0 Comments

I can’t seem to find the source I read this from, but if I remember correctly, caffeine works by binding to parts of your brain called adenosine receptors. Adenosine is responsible for regulating your sleep-wake cycle. However, just because these receptors are being taken up by the caffeine doesn’t mean that the adenosine is going away. It builds up in your system and you eventually reach a point where there is much more adenosine floating around in your body than there is caffeine, even if you drink more coffee. It eventually wins out, binds to the receptors, and makes caffeine less effective.

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